In the 2010s, Wade Guyton continued to explore and expand upon his innovative use of technology in art, further establishing his reputation as a leading figure in contemporary art. Guyton's practice of running linen canvases through inkjet printers, embracing the glitches and inconsistencies inherent in the process, remained central to his work. This decade saw him incorporating even more modern technology into his art, such as screenshots and camera phone snapshots, alongside recurring motifs like geometric shapes, the color black, flames, and the letters 'U' and 'X'. These elements underscore his ongoing interest in the digital era's impact on our relationship with images​ (Ocula Art)​. Guyton's collaborative efforts with Kelley Walker under the name Guyton\Walker also persisted, with their work delving into themes of consumption and advertising through the appropriation of images printed on three-dimensional objects. This partnership highlighted a contrast to Guyton's more color-minimalist solo pieces by producing works that were vibrant and saturated, reflecting consumer culture's overstimulation​ (Ocula Art)​. The 2010s were marked by significant exhibitions and achievements for Guyton. Notably, his solo shows at major institutions like the Museum Ludwig in Cologne and the Serpentine Gallery in London, among others, showcased his contributions to contemporary art. Additionally, Guyton's work in the 'X Poster' series in 2019 to fundraise for the artist book non-profit organization Printed Matter illustrated his engagement with the art community and beyond. His art is held in high regard, with pieces in the collections of prestigious museums worldwide and achieving record prices at auction, reflecting the high market demand for his work​ (Ocula Art)​. A standout moment in the 2010s for Guyton was his exhibition at Glenstone in 2020–21, where he presented "Untitled," a suite of 26 paintings made during the COVID-19 pandemic. This series captured the collective isolation and uncertainty of the pandemic's first year, featuring a range of images from screenshots to personal photos, presented as sculptural stacks leaning against the wall. This body of work exemplifies Guyton's innovative approach to art-making and his ability to capture and reflect contemporary experiences​ (Glenstone)​. Throughout the 2010s, Wade Guyton's art remained at the forefront of discussions about the intersection of technology and art, illustrating his capacity to innovate and adapt to the changing digital landscape.