Martin Kippenberger's "The Raft of the Medusa" series, created in 1996, stands as a profound testament to the artist's introspection and commentary on human fragility, staged against the backdrop of his own mortality. This series, taking inspiration from Théodore Géricault’s iconic painting "The Raft of the Medusa" (1818–19), encompasses a sprawling multimedia project that includes paintings, drawings, lithographs, and even a large rug depicting the schematic layout of the raft​ (e-flux)​.

In his final year, with his health declining due to liver cancer, Kippenberger embarked on this ambitious project as a series of self-portraits, working from photographs taken by his wife, Elfie Semotan. These works not only draw a parallel to Géricault’s depiction of the desperate survivors of a shipwreck but also delve into the existential themes of life, death, and the artist's contemplation of his own existence. Kippenberger portrayed himself in various states of vulnerability, reflecting on the human condition's inherent precariousness. Through these images, he presents himself as both a participant and observer, entwined in the historical narrative of survival and despair.

The series was significant for its encompassing approach to art-making, uniting a variety of mediums to express a cohesive thematic exploration. This multimedia dimension allowed Kippenberger to layer meanings and references, connecting his immediate physical condition to broader human experiences and historical narratives​ (TheValue.com)​.

The comprehensive nature of "The Raft of the Medusa" series was highlighted in its first New York exhibition at Skarstedt, organized in collaboration with the Estate of Martin Kippenberger at Cologne’s Galerie Gisela Capitain. The exhibition displayed the depth and breadth of Kippenberger's creative vision, showcasing the series' paintings, lithographs, and the significant rug, among other elements​ (ArtDaily)​.

Kippenberger’s work in this series is a poignant reflection on his battle with mortality, positioning himself as both victim and commentator. His artistic legacy, marked by a blend of humor, flamboyance, and a nuanced understanding of human fragility, ensures that "The Raft of the Medusa" remains a compelling examination of the artist's introspective journey and a critical commentary on the human condition​ (TheValue.com)​.