Adrian Ghenie's work is rich in art historical references, melding personal and political narratives with elements drawn from the history of art. His paintings are known for integrating techniques from different art-historical periods, such as the dramatic chiaroscuro of the Renaissance and the gestural immediacy of Abstract Expressionism. This blending of styles serves not only to showcase Ghenie's technical prowess but also to reflect on the turbulent underpinnings of local and global histories​ (Thaddaeus Ropac)​.

Ghenie's exhibitions often feature new oil paintings and charcoal drawings that reflect significant shifts in his artistic direction, demonstrating his continuous exploration of contemporary existential fears through the lens of historical and art historical imagery. His solo exhibitions have been held in prestigious galleries and museums across the world, indicating the international recognition of his work. Notable exhibitions include "The Fear of NOW" at Thaddaeus Ropac, London, and "We Had Everything Before Us" at Galerie Judin, Berlin, showcasing Ghenie's engagement with contemporary issues through the medium of painting​ (Thaddaeus Ropac)​.

Ghenie does not shy away from confronting the darkest chapters of history, often invoking the imagery of notorious historical figures and traumatic events to probe deeper into the collective consciousness. His work, therefore, acts as a bridge between the past and the present, urging viewers to reflect on how history's shadows continue to shape our current reality .

Moreover, Ghenie's participation in major international exhibitions, such as the Venice Biennale, where he represented Romania with "Darwin's Room," underscores his role in contemporary discussions on evolution, survival, and societal transformation. This particular series delves into Charles Darwin's theories, using them as a metaphor to explore broader societal changes and the impact of historical events on human development and ideologies​ (Adrian Ghenie - Darwin's Room)​.

Adrian Ghenie's paintings are a profound meditation on history, memory, and art's power to comment on and critique both. His art historical references serve not only as tributes to the masters who preceded him but also as tools for dissecting and understanding the complex layers of human history and psychology.